Case-cohort study designs represent a cost-effective and efficient strategy for analysing time-to-event data, particularly when the event of interest is rare. By selecting a random subcohort along ...

Objective To characterise the risk of subsequent primary non-keratinocyte skin cancers (NKSCs) among adult-onset cancer survivors. Design Data analysis of this population-based cohort study was ...

As biomarker studies employ increasingly complex and expensive genomics and other correlative methods, it is increasingly important to rigorously design these studies and analyze the downstream ...

Background Aortic stenosis (AS) frequently coexists with heart failure (HF), but its prevalence, prognostic impact and management across the full HF spectrum remain incompletely characterised. Methods ...

Objective To estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population. Design Systematic ...

A landmark German study finds that mRNA COVID-19 vaccination during the first trimester does not increase the risk of major congenital disabilities, offering crucial reassurance for expectant parents ...