R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

Why do some tumors spread while others remain localized? The mechanisms governing the metastatic potential of tumor cells ...

Summary: A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can ...

Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...

By profiling gene expression in colon cancer cell clones, researchers identified signatures linked to metastatic risk and built an AI model that predicts spread and recurrence with high accuracy.

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as reported by researchers from Science Tokyo. The team engineered mice to produce ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

A gene based model using nasopharyngeal carcinoma biomarkers AURKA and BUB1 accurately predicts survival and demonstrates ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...